2013). How does Regu-Mate Solution work? Ingredients Contains altrenogest 2.2 mg/mL in an oily solution. Regumate Equine is used to control oestrus ("heat") in mares. Decisions of the FEI General Assembly pertaining to Veterinary matters Authorisation of treatment with altrenogestThe Assembly approved a proposed rule change enabling the treatment of mares with excessive oestrus behaviour with Regumate® (altrenogest), under the following conditions:1. only for mares,2. Simply apply the Regu-Mate solution at either the base of the mare's tongue or directly on her grain. Regumate is the most widely used drug in controlling mare behavior. Strengths: 2 strengths of Altrenogest Injection Solution are available, ranging from 150 mg/ml to 225 mg/ml. Like progesterone birth-control pills or implants, it suppresses estrus by tricking the brain into thinking the mare is pregnant. Detach syringe and administer solution orally at the rate of 1 mL per 110 pounds of body weight (0.044 mg/kg) once daily for 15 consecutive days. ll natural product to help your mare get off hormones and shots. This study provided the following data: Para a sincronização do cio das marrãs, administrou-se: progestágeno altrenogest (Regumate®, MSD Saúde Animal) (20 mg) por 18 dias; gonadotrofina coriônica equina (eCG-Novormon®, Zoetis), 24 horas após a retirada do altrenogest na dose de 600 UI e 2,5 mg do hormônio liberador de Gonadotrofinas (GnRH - Sincrofort®, Ouro Fino), como . For owners or exhibitors of mares, you will be limited to the use of Regumate to control estrous. She then proceeded to tell me that on a hunch, she dosed these mares with Regumate to inhibit their cycles.. just in case the heat cycle was the trigger. Regu-Mate requires a prescription from your veterinarian. REGU-MATE (altrenogest) Solution 0.22% is contraindicated for use in mares having a previous or current history of uterine inflammation (i.e., acute, subacute, or chronic endometritis). Treated mares received 2 mL Regumate solution 0.22%/110 lb body weight (2x dosage recommended for estrus suppression) from day 20 to day 325 of gestation. 2. This study provided the following data: In filly offspring (all ages) of treated mares, clitoral size was increased. a Grade II or greater uterine biopsy result), or current uterine inflammations (i.e. Altrenogest is also used in the support of high-risk pregnancies at twice the normal dose or 0.088 mg/kg, which is approximately 2.0 mL per 110 lbs of body weight. Beside this, how do you use mare Regumate? 10 to 50 µg, IM, q 6 h to 12h. The Regu-mate Dosing Device helps to make dosing easy. Replace cover on bottle dispensing tip to prevent leakage. Active ingredient: Altrenogest. It's easy to administer &ndash orally or top-dressed on grain. Regu-Mate Solution 0.22% produces a progestational effect in mares. Hormone free and totally safe to handle. Dosage and Administration: Treatment of placentitis-affected mares with a double-dose of the oral version of altrenogest "Regumate ® " has been suggested, [22] [23] but while beneficial under the circumstances, the effect of this dosage on "forced" maintenance of an undesirable pregnancy has . As you already know,giving Regumate daily is to provide a progesterone-type hormone to aid in maintaining the pregnancy through day 90-120. Treated mares received 2 mL Regu-Mate ® (altrenogest) Solution 0.22% /110 lb body weight (2 × dosage recommended for estrus suppression) from day 20 to day 325 of gestation. Treated mares received 2 mL Regumate porcs solution 0.22%/110 lb body weight (2x dosage recommended for estrus suppression) from day 20 to day 325 of gestation. Administer solution directly on the base of the mare's tongue or on the mare's usual grain ration. The Regumate needed to be given daily, as near exact the time as possible.never skip a dose. This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. However, what is the clinical evidence for . Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal, which permits scheduled breeding of mares during the breeding season. Questions & Answers Product Description Regu-Mate Solution Indicated to suppress estrus in mares. High plasma progesterone levels in mares suppress oestrus behaviour. Oral administration of altrenogest to mares at a dose of 0.044 mg/kg body weight for 15 days resulted in intervals to estrus and ovulation of 5.0 ± 2.4 days and 10.2 ± 3.6 days, respectively. This allows a regular cycle during the transition from winter anestrus to the physiological breeding season in mares with active ovaries. Regu-Mate Solution 0.22% is indicated to suppress estrus in mares. Regu-Mate is a solution for oral use only and is available in a 1,000 ml bottle. Product: Regumate® Equine 2.2 mg/ml oral solution for horses. Regumate® can be used to accomplish both tasks. Management. Regumate fans often say it makes the mare feel "content" — their reasoning being that pregnant mares feel "content." It is meant to be used for the suppression of estrus in mares. Efficacy studies were performed on Thoroughbred horses with an average weight of 500kg using a dose of 3 mL per horse every 7 days. Trending A Blue Whale'S Tongue Weighs More Than An Elephant? Theriogenology 66 (2006) 686. Regumate Equine is a clear, light yellow oily solution. Regu-Mate® (altrenogest) nih.gov Helps settle squealing and excess flirting. Helps reduce sensitivity to being groomed or tacked-up. Consequently, endogenous progesterone levels may be monitored while a mare is being treated with altrenogest. It makes measuring the dose as easy as turning a dial, and limits skin exposure to the drug. on the secretion of luteinising hormone, via a negative. Wedgewood Pharmacy's stringent quality control programs help ensure that our injection solutions meet the specifications and high standards of the pharmacy industry. If a mare's problems are hormonal, it will work, provided the dose is sufficient and it's used absolutely on order. Administer solution directly on the base of the mare's tongue or on the mare's usual grain ration. Each ml of Regumate Equine contains Altrenogest 2.20 mg as active sustance and Butylhydroxyanisole (E3210) 0.07mg, Butylhydroxytoluene (E321) 0.07mg, Sorbic acid (E200) 1.50mg and Benzyl alcohol 10.00mg as excipients. The same formulation and active ingredient a Regu-Mate®. When treatment is discontinued, mares return to estrus within 4 to 5 days. The mare will experience a predictable occurrence of estrus following drug withdrawal. The Ergonomic design gives maximum user comfort and stylish looks. Pharmacokinetic data from mares treated with Ovu-Mate, have shown blood levels of altrenogest are maintained for 5 days following administration of the injection. The only multi-herbal mare product you can show and race on. Pregnant women or women who suspect they are pregnant should not handle Regu-Mate®. As low as 1.25 to 2.5 mg has induced a normal estrus in 11 mares with 32 cycles (Barker. Altrenogest is not detected in commercial progesterone assays. Therapeutic indication: Pharmaceuticals: Hormones and therapeutically related products: Other sex hormones. All 4 mares got better within 24 hours - and continued to improve. Money back guarantee to improve your mare's health and comfort. Regu-Mate is for administration orally on back of mare's tongue or applied to usual grain ration. Buserelin *. I use regumate (porcine) with my mare basically from the first sign of first season - was Feb this year - until Sept/October. Regumate Equine is used to control oestrus ("heat") in mares. The mares I took care of were of top bloodlines and worth a fortune. The cost-effective alternative to Regu-Mate®. Regumate Equine 2,2 mg/ml 1000 ml. The mare is subsequently administered hCG to induce ovulation; note that administration of a 'high-dose' of deslorelin (i.e. It is supplied as a liquid to be given directly into the mouth or added to a small amount of food. Why use Regu-Mate Solution? The usual dose is 1 ml per 110 lbs body weight once daily for 15 consecutive days. How rapidly does Regumate work? Many show mares are on it year round and at a higher dose than the recommended . Helpful. Clinical uses of Regumate include management of the transition period, suppression of heat in performance mares and maintenance of pregnancy in problem mares. Regu-Mate Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. One of the mares in the treatment group died as a result of an intestinal crisis in week 10 and results for . Active Ingredients: Each ml of Regu-Mate (altrenogest) Solution 0.22% contains 2.2 mg of altrenogest in an oil solution. Your records should clearly indicate which mares are . Regu-Mate altrenogest Solution 0.22% produces a progestational effect in mares. Studies have been conducted to support suppression of behavioural signs of oestrus in cycling mares for 7 days following administration of Altrenogest Injection. "The reality is that many of these mares that are on it every day for months and months, it's not a cyclical behavioral issue," he said. In daily stud practice mares are often supplemented with exogenous progestin (altrenogest, Regumate™) as a result of suspicions of inadequate progesterone production or a clinician's frustration when facing mares that repeatedly fail to conceive or carry a pregnancy to term (Canisso et al. 3mL per 500kg bodyweight by intramuscular injection once every 5-7 days as required to suppress signs of oestrus. Regu-Mate is a solution for oral use only and is available in a 1,000 ml bottle. Dosage Administer orally with dose syringe or by placing directly on feed. Species: Horses and other equidae. If Regu-Mate is added to feed, any medicated feed left over should be destroyed and should not be given to other animals. ReguMare helps support the normal hormonal balance of your mare when temperament and marish behaviour adversely affects safe handling, willingness to work and performance. Regumate is a progesterone. Regu-Mate ® (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal in mares with ovarian follicles 20 mm or greater. Progestin treatment. Pregnant mares should gain weight moderately during pregnancy and have a natural glow to their coats. 1.8 mg) is less effective at inducing ovulation in low-dose deslorelin treated mares; Low-dose deslorelin therapy is MORE EFFECTIVE IN TRANSITIONAL MARES than mares in deep anestrus Regu-Mate requires a prescription from your veterinarian. Meg is on it permanently. It contains the active synthetic progestin - altrenogest. It has however been shown that mares will "foal through Regumate" . Regu-Mate Solution 0.22% produces a progestational effect in mares. Oral progestin solution for suppression of estrus in mares. Progesterone and related natural hormones are released from the corpus luteum on the ovary and from certain structures of the placenta. Side effects include transient sweating and colic. Therapeutic indication: Pharmaceuticals: Hormones and therapeutically related products: Other sex hormones. n Regu-Mate effectively suppresses estrus in 95 percent of mares after 3 days of treatment. Available in 1000 mL bottles along with a dispensin cap. Regumate Equine is used to control oestrus ("heat") in mares. INDICATIONS: Regu-Mate ® (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. Mare Support REGUMARE helps support the normal hormonal balance of mares when temperament and marish behaviour adversely affects safe handling, willingness to work or focus in the ring or on the track. Mare Health. Regumate Equine 2,2 mg/ml 1L. dose rates to sedentary mares had no effect on dominance . Administered orally as an oil solution, the labeled dose of altrenogest is 0.044 mg/kg (1 ml per 110 lb of body weight). Regu-Mate® is contraindicated for use in mares having a previous or current history of uterine inflammation. Hormones with progesterone-like activity are called progestanes. Alternatively, a dose of 0.1 to 0.5 mg (0.1 cc) given twice at a 24 hr interval can be used. Regumate is the trade name for a synthetic hormone called altrenogest. Nr. It can be given daily to a mare early in her season and usually within 3 days it will stop that oestrus. Regumate is a progesterone. The dose is 5-10 mg (1-2 cc/mare) IM. It contains the active synthetic progestin - altrenogest. Species: Horses and other equidae. It can be given daily to a mare early in her season and usually within 3 days it will stop that oestrus. Suppression of behavioral estrus, synchronization of estrus, maintenance of pregnancy. Active Ingredients: Each ml of Regu-Mate (altrenogest) Solution 0.22% contains 2.2 mg of altrenogest in an oil solution. Regumate® Equine 2.2 mg/ml oral solution for horses. donor mare with a specific recipient mare. Administering prostaglandin on the last day of treatment may improve results if the mare(s) ovulated during treatment. Altrenogest (Regu-Mate ®) (2.2 mg/ml) 0.088 mg/kg, orally, q 24h or 0.044 mg/kg, orally, q 12h (double dose) Maintenance of pregnancy in high risk mares. acute, subacute or chronic endometritis). DOSAGE CHART: Approximate Weight In Pounds Dose in mL 770 7 880 8 990 9 1100 10 1210 11 1320 12. Horses: Regu-Mate ® Solution 0.22% is contraindicated in pregnant mares and in mares having a previous history of uterine inflammation (i.e. When you removed the Regumate the cycling, the moodiness, the soreness and the teasing of the stallions returned really fast. It is the only such medication proven to have progesterone-type biologic activity in the horse. HI, I'm Dr Steve. Once again, we have to ask "does my mare need Regumate", and if there is not a clear indication of continued low progesterone levels (generally 4 ng/ml is considered sufficient to maintain pregnancy, although 2 ng/ml is considered sufficient by some researchers 5 ), then the answer is probably "no". $ 140.00 $ 110.00. Consult with your veterinarian for any potential side effect concerns. The recommended dosage of Regu-Mate is 1 ml per 110 lbs body weight given once daily for 15 consecutive days. Altrenogest is used for suppression of estrus. n Regu-Mate lets you breed earlier in the season by helping transitional mares cycle . Regu-Mate® is used to conveniently suppress estrus in mares, control the time that estrus starts, and shorten prolonged estrus. 2 people found this helpful. Regu-Mate is for administration orally on back of mare's tongue or applied to usual grain ration. Natural or synthetic gestagen therapy may exacerbate existing low-grade or 'smoldering' uterine inflammation into a fulminating uterine infection in some instances. Regumate® is occasionally administered off-label to stallions in an attempt to suppress undesirable male behavioral characteristics Any discharge from the vulva warrants a call to your veterinarian. Are there any side effects? Administer with a dose syringe or add to grain ratio n Regu-Mate can help alleviate moodiness and temperament changes associated with estrus. This study provided the following data: 1000ml What is Regu-Mate Solution? Effective only in mares during late transitional phase: Altrenogest (Regu-Mate) Intervet/Shering-Plough: 0.044 mg/kg/day orally for 10-15 days: Effective only in mares during late transitional phase. DOSAGE AND ADMINISTRATION. Facilitates scheduling of mares during the breeding season. Like progesterone birth-control tablets or implants, it suppresses estrus by tricking the mind into pondering the mare is pregnant. Further, it is considering also prohibiting the use of a stronger progestin, Altrenogest or Regumate, in all geldings and stallions. Active ingredient: Altrenogest. The Dial-A-Dose system (2mL to 15mL) allows for an easy setting of dosage and accuracy of dosage. Altrenogest (Intervet, Millsboro, DE) is a synthetic progestin approved for use in horses for the purpose of suppressing estrus. Regumate can continue to be given once daily afterwards to prevent the return to oestrus. The recommended dosage of Regu-Mate is 1 ml per 110 lbs body weight given once daily for 15 consecutive days. GnRH agonist; stimulation of follicular development in . The usual dose is 1 ml per 110 lbs body weight once daily for 15 consecutive days. This study provided the following data: 1. WHICH MARES WILL RESPON D TO REGU-MATE® (altrenogest) SOLUTION 0.22%: Extensive clinical trials have demonstrated that estrus will be suppressed in approximately 95% of the mares within three days; however, the post-treatment response depended on . In filly offspring (all ages) of treated mares, clitoral size was increased. What's in it? The regumate I am feeding is pig regumate which consists of a different proportion of altrenogest to horse regumate, and the dosage of pig regumate for a horse of Meg's size is 6mls, so I am feeding over double the recommended dose in order to keep the symptoms I have described above at bay. For the suppression of oestrus in normally cycling mares. Regu-Mate (altrenogest) Solution 0.22% is indicated to suppress estrus (period of the reproductive cycle when the mare ovulates and, if bred, is likely to conceive) in mares. Allows for predictable occurrence of estrus following withdrawal of the drug. TOP TIP you can get regumate porcine which is essentially the same thing but designed for pigs - heaps cheaper - like £60 a bottle and works just as well. I wouldn't want to use Regumate without this device-nobody needs extra exposure to these kinds of hormones. Regumate® Equine 2.2 mg/ml oral solution for horses. Some mares seem to need to stay on it year 'round though, and they will obviously come in to season when it's stopped (which is why it's often used to cycle mares for breeding purposes) which . This leads him to believe they aren't getting it just to manage the side effects of ovulation. Five mares served as infected, untreated control animals (Group UNTREAT). Not a subscriber? feedback effect on the hypothalamic-pituitary axis. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. Possible Side Effects When used as directed on the label, Regu-Mate is usually tolerated well by horses. in mares that have previously lost their foal to placentitis, although there is not scientific data to support the protocol, is to give these mares, antibiotics and flunixin meglumine, for the first 10 days of the month beginning around the 7th month of gestation. 17 At the beginning of week 9 (treatment period) mares were randomly divided into two groups with six mares treated daily with altrenogest (Regumate, Hoechst Roussel) at the recommended dose rate of 0.044 mg/kg body weight per os by syringe.

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